![]() Avery and his colleagues isolated polysaccharide, which makes up the capsular envelope of the pneumococcus. In 1913, he began research on the Streptococcus pneumoniae, the causative agent of lobar pneumonia. Fig 1: The process of Transformation.Īvery had a medical degree but later was drawn to the bacteriological research. Eventually, Avery and team‘s experiment revealed the nature of the principle of the transforming principle. At this point, the scientists were unsure if the transforming factor was a protein or DNA. It was found that the transforming principle could be precipitated with alcohol, which showed that it was not a carbohydrate like the polysaccharide coat itself. However, Griffith could not exactly find the nature of the transforming particle. ![]() He found that the dead S bacteria, which was encapsulated and virulent, could transform the non-virulent, non-encapsulated live R bacteria into encapsulated and virulent S bacteria. We have seen in the previous post that in 1928, Frederick Griffith discovered the process of transformation in Streptococcus pneumoniae. ![]()
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